It markedly attenuates or completely blocks,reversibly, the subjective effects of intravenously administered opioids. The safe use of naltrexone hydrochloride in pediatric patients younger than 18 years old has not beenestablished. Naltrexone (100 mg/kg/day 600 mg/m2 /day PO; 16 times the recommended therapeutic dose, based onbody surface area) caused a significant…
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